From December, the airline will operate three flights a week on Monday, Thursday and Sunday to Tel Aviv while a weekly Thursday flight will got to Ovda.
One-way flights will lead in at £89 outbound and £49 inbound with flight times of around five hours.
Once they have landed, travellers to Tel Aviv will find they are 25 minutes from the city and 50 minutes from Jerusalem while Ovda airport is 45 minutes from beach resort Eilat.
Andrew Swaffield, chief executive of The Monarch Group, said: “These two new scheduled routes are the result of the ongoing work we are doing to develop our winter programme which showcases a number of winter sun and ski destinations.
“Tel Aviv and Ovda are growing in popularity once more with tourists and with the diverse offerings of both these destinations we are sure they will be a very popular choice for winter short breaks and holidays. We are also looking forward to welcoming visitors from Israel to the UK.”
Yariv Levin, Israel’s minister of tourism, added: “I am delighted that Monarch Airlines is launching new scheduled services to Israel this December.
“This is a great indication that Israel has the support of major carriers, such as Monarch, and will allow for even greater choice and accessibility for international travellers.
By signing the Open Skies Agreement in 2013, we have paved the way to form this partnership with Monarch.”