A total of 2,087,149 people travelled through facility during the month, a 4% increase year on year.
The increase meant the rolling annual total of passengers has hit a new high of 22,955,790 and the airport is confident that it will break the 23 million mark before the end of the year.
The increase was driven by a 7% increase in scheduled flights as football fans poured into the city after both local teams, City and United, secured Champions League qualification.
Charter flights were also boosted by the sport with fans flying to and from Bournemouth and Dublin.
Managing director Ken O’Toole said: “October has been another very positive month with strong growth nudging us toward the 23 million passenger mark.
"We are seeing more and more passengers ’Fly Manchester’, which is evident after our most successful year on record.
“With our two full length runways and a £1 billion transformation program announced, Manchester airport has, and will continue to have, the available capacity and demand to meet the needs of our catchment area that extends as far north as Scotland and south to the Midlands."
An average of 67,327 people flew via Manchester every single day during the 31 days of October – including The Chinese President, Xi Jinping, who visited as part of his state visit to the UK.
While at the airport the president announced new direct flights to Beijing with Hainan Airlines, which start in June 2016 which makes Manchester the only airport outside of London to offer a direct scheduled service to mainland China.