The RMT union said members will walk out for 48 hours on April 28 and 29 due to an ongoing row over guards and jobs.
Having run a full timetable on October 3 when RMT members held a 24-hour strike, the company has pledged to do its best again.
David Horne, managing director for Virgin Trains on the east coast said, “We have worked hard to ensure there are comprehensive contingency plans in place and I want to reassure our customers that our timetable will be almost completely unaffected during this walk-out, as well as during any subsequent strikes by the RMT.
“Passengers can book and plan their journeys as normal and with confidence.
“The changes we have made are part of the customer-centric revolution that’s underway on the east coast.”
